TV series
Former high school lab partners Marshall and Frances begin to unravel a conspiracy involving big pharma and the federal government to suppress knowledge of a rare mushroom that may hold the key to curing all the world’s diseases.
Streaming, rental and purchase options
Checked Sep 5, 2026
Common Side Effects is available to stream on DirecTV On Demand, HBO (Via Hulu), HBO Max, HBO Max (Via Amazon Prime), and YouTube TV in United States. You can also buy it from Amazon, Apple TV, and Fandango at Home. Use the direct links below to open the provider.
Former high school lab partners Marshall and Frances begin to unravel a conspiracy involving big pharma and the federal government to suppress knowledge of a rare mushroom that may hold the key to curing all the world’s diseases.
Choose an episode, then use the watch options above for the show.
Episode 1
Marshall meets his old high school classmate Frances and lets her in on a world-changing secret.
Directed by Camille BozecWritten by Joseph Bennett, Steve HelyGuest stars Shalita Grant, Ben Feldman, Shannon Woodward
Episode 2
Marshall's forced on the run as the DEA pursues him.
Directed by Sean BuckelewWritten by Steve HelyGuest stars Alan Resnick, Timothy Simons, Bob Stephenson, Ben Feldman, Sydney Tamiia Poitier, Sue Rose, Shannon Woodward, Danny Huston
Episode 3
Marshall visits an old mentor as new pressures mount.
Directed by Vincent TsuiWritten by Emma BarrieGuest stars Andy Daly, Shalita Grant, Lin Shaye, Bob Stephenson, Ben Feldman, Sydney Tamiia Poitier, Sue Rose, Shannon Woodward
Episode 4
Frances tracks down Marshall in an unlikely location.
Directed by Camille BozecWritten by Jean Kyoung FrazierGuest stars Shalita Grant, Lin Shaye, Ben Feldman, Sue Rose, Steve Hely, Shannon Woodward
Episode 5
Marshall, Frances, and their crazy neighbors deal with the aftermath of a dangerous incident.
Directed by Sean BuckelewWritten by Dave KingGuest stars Nicolas Cantu, Sydney Tamiia Poitier, Sue Rose, Danny Huston, Steve Hely
Episode 6
Stuck in jail, Marshall faces new threats.
Directed by Vincent TsuiWritten by Jon FoorGuest stars Lin Shaye, Jon Foor, Timothy Simons, Sydney Tamiia Poitier, Sue Rose, Danny Huston, Steve Hely, Christine Ko
Episode 7
A chance encounter offers a risky opportunity for escape.
Directed by Camille BozecWritten by Karey DornettoGuest stars Jon Foor, Andy Daly, Shalita Grant, Sydney Tamiia Poitier, Shannon Woodward, Christine Ko, Ben Feldman
Episode 8
Marshall and his new ally make a bold move.
Directed by Sean BuckelewWritten by Daniel SchofieldGuest stars Alan Resnick, Jon Foor, Shalita Grant, Ben Feldman, Sydney Tamiia Poitier, Sue Rose, Shannon Woodward, Danny Huston
Episode 9
Marshall's mushroom project grows out of hand.
Directed by Vincent TsuiWritten by Sophie KriegelGuest stars Alan Resnick, Shalita Grant, Timothy Simons, Sydney Tamiia Poitier, Sue Rose, Shannon Woodward, Danny Huston, Steve Hely
Episode 10
Dangerous forces converge on Marshall's camp.
Directed by Camille BozecWritten by Steve HelyGuest stars Bob Stephenson, Ben Feldman, Sue Rose, Shannon Woodward, Danny Huston, Steve Hely, Christine Ko
Episode information updated Sep 18, 2026
Dave KingMarshall Cuso (voice)
Emily PendergastFrances Applewhite (voice)
Mike JudgeRick Kruger (voice)
Martha KellyAgent Harrington (voice)
Joseph Lee AndersonAgent Copano (voice)
Alan ResnickZane (voice)
Lin ShayeSonia (voice)
Andy DalyMysterious Passenger (voice)
Adult SwimUnited States
Green Street PicturesUnited States
Williams StreetUnited States
