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Entering their first year as residents, Meredith Grey, Cristina Yang, Izzie Stevens and Alex Karev now have interns of their own to mentor. Among the new interns are George, forced to repeat his internship after failing his exams, and Lexie Grey, Meredith's half-sister. Another two new interns will be introduced in this season premiere. And they'll have their hands full when a three-car accident sends multiple casualties pouring into Seattle Grace. Some of the doctors need to deal with new stressed out interns. A young boy brings his bleeding deer to the hospital in the hope a doctor will save her.
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Directed by Michael Grossman, Rob CornWritten by Shonda RhimesGuest stars Mac Brandt, Gloria Garayua, Candice Afia, Mark Pellegrino, Richard Keith, Molly Kidder, Joe Williamson, Winston Story
A patient is in the hospital because they fell asleep in a hazardous situation. A patient's home laboratory blew up in an apartment building and the victims flood the hospital. Alex investigates the cause of the incident by talking to a really old guy who lived in the building. Jane Burke shows up to deal with what her son left behind. Lexie tries to talk to Meredith. Callie is overwhelmed by her new position while Bailey is searching for things to do.
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Directed by James FrawleyWritten by Debora CahnGuest stars Diahann Carroll, Moe Irvin, Mark Saul, Ray Ford, Candice Afia, Ben Vereen, Nicholas Gonzalez, Brooke Blanchard
The doctors meet the world's oldest intern. Marcy brings in her son Henry because she finds his change in behavior suspicious. A patient named Connie may lose her vocal chords unless Mark and Richard can perform a radical new surgery. George impresses the other interns at work but at home he is trying to deal with his guilt about having sex with Izzie.
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Directed by Daniel MinahanWritten by Mark WildingGuest stars Gloria Garayua, Moe Irvin, Mark Saul, Ray Ford, Candice Afia, Richard Keith, Eve Gordon, Amy Hill
A face familiar to one of the year-twos shows up and dredges up issues that were never really dealt with. A teen soccer player needs counseling because of his father and surgery for an injury he sustained while playing the game. Another patient's, named Courtney, finds out that her cancer is back.
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Directed by Randall ZiskWritten by Allan HeinbergGuest stars Loretta Devine, Ron Melendez, Jeremy Rabb, Maile Flanagan, Gloria Garayua, Mark Saul, Richard Keith, Edward Herrmann
It's Halloween at Seattle Grace! There may be jokes, pranks, and/or scare tactics. Some of the women form a club based on an experience they all share. A man volunteers for what most of the doctors believe is an unnecessary surgery. One of the patients is in the hospital because they tried to carve a pumpkin in an unconventional manner.
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Directed by Bethany RooneyWritten by Krista VernoffGuest stars Brooke Smith, Dylan Minnette, Ray Ford, Sarah Utterback, Rocky Carroll, Kali Rocha, David Clennon, Elizabeth Reaser
A patient comes to the ER with a dream and a condition which may prevent him form realizing it. Two patients are competing to win something big. One of them convinces an intern to take their place.
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Directed by Tom VericaWritten by Stacy McKeeGuest stars Brooke Smith, Amanda Loncar, Steve Sandvoss, Tommy Dewey, David Denman, Cullen Douglas, Nicole Cummins-Rubio, John Cappon
Izzie and George's new-founded relationship results in them having bad sex. Callie's Chief Resident position is taken away from her, and Bailey is the humble replacement. Meredith can barely handle it with Lexie anymore.
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Directed by Jeff MelmanWritten by Joan RaterGuest stars Brooke Smith, Jeff Perry, David Burke, Mark Saul, Stephanie March, Vicki Lewis, Rockmond Dunbar, Enuka Okuma
There has been a bus crash and the patients are in the ER. Meredith and Derek's relationship gets more complicated when he dates a fellow doctor. Meredith's dad goes to visit her at the hospital.
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Directed by Tom Verica, Rob CornWritten by Mark WildingGuest stars Brooke Smith, Jeff Perry, Mark Saul, Ray Ford, Brooke Nevin, D. B. Woodside, Madeline Zima, Kali Rocha
An ambulance crash endangers the lives of the paramedics involved, as Meredith and the Chief work on-site to save them, Bailey treats a patient who refuses her help, and Ava returns for Alex and meets his other girlfriend in the process.
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Directed by Michael GrossmanWritten by Krista Vernoff, Shonda RhimesGuest stars Brooke Smith, Cress Williams, Theo Rossi, Mark Saul, Ray Ford, Linda Klein, Candice Afia, Lauren Stamile
Meredith works furiously to save a paramedic trapped in an ambulance; Lexie holds the life of a patient in her hands; Derek must rely on a nurse to save a patient; Bailey struggles to balance her personal life with her work.
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Directed by Jessica YuWritten by Krista Vernoff, Shonda RhimesGuest stars Brooke Smith, Cress Williams, Theo Rossi, Patricia Bethune, Moe Irvin, Mark Saul, Ray Ford, Kate Anthony
George has a surprise visitor. Bailey's family is falling apart. Derek sorts through what kissing Rose means. Meredith discovers something that doesn't inspire hope or happiness in her. Alex treats a faith healer.
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Directed by John TerleskyWritten by Allan HeinbergGuest stars Brooke Smith, Cress Williams, Debra Monk, Lauren Stamile, Glenne Headly, Carol Locatell
Time has passed but not much has changed. Sexual angst still runs rampant in the halls of Seattle Grace. Derek and Rose have been dating and Meredith has noticed the activities of her current off-again ex-boyfriend. The doctor's are in the midst of a competition.
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Directed by Rob CornWritten by Zoanne ClackGuest stars Brooke Smith, Clea DuVall, Amy Madigan, Lauren Stamile, Jason O'Mara, Steven Flynn, Cheech Marin, Troy Westbrook
Addison visits Seattle Grace because they need skills that only she has. Rebecca/Ava returns with news for Alex. Meredith and Derek's clinical trial experiences one or two developments.
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Directed by Mark TinkerWritten by Stacy McKeeGuest stars Kate Walsh, Brooke Smith, Clea DuVall, Gloria Garayua, Amy Madigan, Lauren Stamile, Elizabeth Reaser, Richard Keith
The clinical trial continues to make progress. The anti-McSteamy club creates new initiatives but that isn't enough to stop one woman from spending time with him. Christina is affected by Burke's career developments.
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Directed by Julie Anne RobinsonWritten by Joan RaterGuest stars Brooke Smith, Loretta Devine, Moe Irvin, Amy Madigan, Candice Afia, Lauren Stamile, John M. Jackson, Zilah Mendoza
Dr. Wyatt refuses to let Meredith give up on therapy. Alex learns something else about Rebecca. The Chief wants Erica to perform a daring surgery. Christina continues to act strangely.
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Directed by James FrawleyWritten by Debora CahnGuest stars Brooke Smith, Cress Williams, Amy Madigan, Lauren Stamile, April Grace, Jeffrey D. Sams, Paul Dooley, Regina Taylor
A couple undergoes surgery. Derek and Meredith's clinical trial gets a second shot from a new patient. Izzie helps Alex. McSteamy hooks up with someone.
Episode credits
Directed by Rob CornWritten by Shonda RhimesGuest stars Brooke Smith, Jurnee Smollett, Amy Madigan, Lauren Stamile, Sterling Knight, Elizabeth Reaser, John Cothran, Molly Kidder
A couple undergoes surgery. Derek and Meredith's clinical trial gets a second shot from a new patient. Izzie helps Alex. McSteamy hooks up with someone.
Episode credits
Directed by Rob CornWritten by Shonda RhimesGuest stars Brooke Smith, Jurnee Smollett, Loretta Devine, Amy Madigan, Lauren Stamile, Sterling Knight, Elizabeth Reaser, John Cothran