
Episode 1
Chapter 1: LSD
From its 1943 origins to today's microdosing trend, LSD has been expanding minds and changing lives with the help of counterculture gurus — and the CIA.
Episode credits
Directed by Lucy Walker

TV series
Author Michael Pollan leads the way in this docuseries exploring the history and uses of psychedelics, including LSD, psilocybin, MDMA and mescaline.
Streaming, rental and purchase options
Checked Jul 22, 2026
How to Change Your Mind is available to stream on Netflix in United States. Use the direct links below to open the provider.
Author Michael Pollan leads the way in this docuseries exploring the history and uses of psychedelics, including LSD, psilocybin, MDMA and mescaline.
Choose an episode, then use the watch options above for the show.

Episode 1
From its 1943 origins to today's microdosing trend, LSD has been expanding minds and changing lives with the help of counterculture gurus — and the CIA.
Directed by Lucy Walker

Episode 2
Magic mushrooms, long considered sacred by the Indigenous Mazatec in Mexico, become the subject of scientific studies measuring their intense effects.
Directed by Lucy Walker, Alison Ellwood

Episode 3
Championed by both therapists and ravers, ecstasy stands out as the first psychedelic likely to become legalized, thanks to passionate advocates.
Directed by Lucy Walker, Alison EllwoodGuest stars Ann Shulgin, Alexander Shulgin, Rick Doblin, Paul F. Daley

Episode 4
Mescaline, the psychoactive molecule in San Pedro and peyote cacti, a sacred medicine that Native Americans have had to fight for the right to use.
Directed by Lucy Walker, Alison Ellwood
Episode information updated Jul 24, 2026
Michael PollanSelf
Ann ShulginSelf - Author, Mentor & Guide Therapist
Alexander ShulginSelf - Chemist, Author & Professor (archive footage)
Rick DoblinSelf - Founder, MAPSMore shows like How to Change Your Mind.