TV series
The mind can be solved.
Two strangers are drawn to a mysterious pharmaceutical trial that will, they're assured, with no complications or side-effects whatsoever, solve all of their problems, permanently. Things do not go as planned.
Streaming, rental and purchase options
Checked Sep 4, 2026
Maniac is available to stream on Netflix in United States. Use the direct links below to open the provider.
Two strangers are drawn to a mysterious pharmaceutical trial that will, they're assured, with no complications or side-effects whatsoever, solve all of their problems, permanently. Things do not go as planned.
Choose an episode, then use the watch options above for the show.
Episode 1
Diagnosed with schizophrenia, Owen is the black sheep of the wealthy Milgrim clan. After losing his job, he enrolls in an experimental drug trial.
Directed by Cary Joji FukunagaWritten by Patrick SomervilleGuest stars Ramya Pratt, Maho Honda, Marlene Ginader, Eric T. Miller, Leo Fitzpatrick, Jojo Gonzalez, Maxine Prescott, Joseph Sikora
Episode 2
When her pilfered stash of pills runs out, troubled Annie tries to quit -- but ends up blackmailing her way into the Neberdine study.
Directed by Cary Joji FukunagaWritten by Patrick SomervilleGuest stars Ramya Pratt, Jacqueline Grabois, Maho Honda, Zach Shearon, Marcus Toji, Rob Yang, Min-wen Huang, Hank Azaria
Episode 3
Muramoto notices irregularities in Annie and Owen's data. He questions Owen, who recalls the worst night of his life: his brother's engagement party.
Directed by Cary Joji FukunagaWritten by Patrick Somerville, Caroline GoddardGuest stars Lauren E. Banks, Olivia Whelan, Trudie Styler, Aaralyn Anderson, James Monroe Iglehart, Dai Ishiguro, Mike Masters, Gabriel Byrne
Episode 4
After taking the B pill, Annie and Owen find themselves on 1980s Long Island entangled in a strange caper involving a lemur.
Directed by Cary Joji FukunagaWritten by Nick Cuse, Patrick SomervilleGuest stars Ramya Pratt, Aaralyn Anderson, Eric T. Miller, Leo Fitzpatrick, Glenn Fleshler, Jojo Gonzalez, Alexandra Henrikson, Alix Korey
Episode 5
Annie and Owen are Arlie and Ollie, grifters attending a séance at the mysterious Neberdine mansion in the 1940s.
Directed by Cary Joji FukunagaWritten by Mauricio Katz, Caroline GoddardGuest stars Lindsey Blanchard, David Fierro, Hank Azaria, Jacqueline Grabois, Glenn Wein, Ariel Kavoussi, Dai Ishiguro, Josh Pais
Episode 6
Azumi tells James the whole truth about the study's snags and urges him to call his estranged mother, an esteemed therapist.
Directed by Cary Joji FukunagaWritten by Nick Cuse, Patrick SomervilleGuest stars Chris Ghaffari, James Monroe Iglehart, Dai Ishiguro, Kathleen Choe, Allyce Beasley, Stephen Hill, Danny Hoch, Julia Garner
Episode 7
Owen and Annie take the C pill. No longer connected, he belongs to a Mafia family, and she's a medieval guide hired by an ailing elf princess.
Directed by Cary Joji FukunagaWritten by Amelia Gray, Danielle HendersonGuest stars Aaralyn Anderson, Trudie Styler, Ariel Kavoussi, Jonathan Rentler, Zach Shearon, James Monroe Iglehart, Dai Ishiguro, Lev Gorn
Episode 8
Annia and Ellia continue their quest, and Owen's mafioso father pressures him to protect the family. Greta counsels a bereaved Gertie.
Directed by Cary Joji FukunagaWritten by Nick Cuse, Mauricio KatzGuest stars Zach Shearon, Aaralyn Anderson, James Monroe Iglehart, Dai Ishiguro, Sissy Sheridan, Mike Masters, Gabriel Byrne, Kathleen Choe
Episode 9
Owen and Annie meet again as a disgraced Icelandic spy and a CIA operative who helps him. Greta implores James to shut down the trial.
Directed by Cary Joji FukunagaWritten by Patrick SomervilleGuest stars Sean Meehan, Louis Arcella, Lukas Hassel, James Monroe Iglehart, Dai Ishiguro, Lev Gorn, Kathleen Choe, Allyce Beasley
Episode 10
After the subjects are discharged, James and Azumi face Neberdine's CEO. Owen and Annie part ways -- until a startling headline sparks a reunion.
Directed by Cary Joji FukunagaWritten by Cary Joji Fukunaga, Patrick SomervilleGuest stars Jacqueline Grabois, Lauren E. Banks, Marlene Ginader, Ben Sinclair, Elaine Bromka, Rob DeRosa, Jennifer Ikeda, Subhash Mandal
Episode information updated Sep 16, 2026
Emma StoneAnnie Landsberg
Jonah HillOwen Milgrim
Sonoya MizunoDr. Azumi Fujita
Ramya PrattVicky / Green Hoodie Woman
Justin TherouxDr. James K. Mantleray
Sally FieldDr. Greta Mantleray
Netflix
Anonymous ContentUnited States
Paramount Television StudiosUnited States
