TV series
William Masters and Virginia Johnson are real-life pioneers of the science of human sexuality. Their research touched off the sexual revolution and took them from a midwestern teaching hospital to the cover of Time magazine and multiple appearances on Johnny Carson's couch. He is a brilliant scientist out of touch with his own feelings, and she is a single working mother ahead of her time. The series chronicles their unusual lives, romance, and unlikely pop culture trajectory.
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Checked Jul 22, 2026
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William Masters and Virginia Johnson are real-life pioneers of the science of human sexuality. Their research touched off the sexual revolution and took them from a midwestern teaching hospital to the cover of Time magazine and multiple appearances on Johnny Carson's couch. He is a brilliant scientist out of touch with his own feelings, and she is a single working mother ahead of her time. The series chronicles their unusual lives, romance, and unlikely pop culture trajectory.
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Episode 1
Masters and Johnson face the press for the first time.
Directed by Jeremy WebbWritten by Michelle AshfordGuest stars Isabelle Fuhrman, Kevin Christy, Eric Lange, Noah Robbins, Peter Douglas, Hanna Hall, Chris Dougherty, Colin Trahan
Episode 2
Masters takes on a high profile patient. Virginia and Libby come to terms.
Directed by Dean PerisotWritten by Amy LippmanGuest stars Isabelle Fuhrman, Kevin Christy, Mather Zickel, Necar Zadegan, Waleed Zuaiter, Maggie Grace, JB Blanc, Christopher Grove
Episode 3
Masters and Johnson look to capitalize on their burgeoning fame.
Directed by Miguel SapochnikWritten by Steven LevensonGuest stars Isabelle Fuhrman, Kevin Christy, Eddie Jemison, Reagan Pasternak, Wendy Worthington, Pete Gardner, Jennifer DeFilippo, Phillip Jordan
Episode 4
Masters seeks unexpected advice. Virginia is distracted by news of Henry.
Directed by Christopher ManleyWritten by Gina FattoreGuest stars Isabelle Fuhrman, Christian Clemenson, Eve Gordon, Sarah Scott, Briggon Snow, Nicole Rochell, Dustin Bayers, Tate Donovan
Episode 5
Johnson's parents arrive unannounced. Masters takes on a promising patient.
Directed by Adam ArkinGuest stars Isabelle Fuhrman, Kevin Christy, Tate Donovan, Allison Janney, Garrett M. Brown, Julie Ann Emery, Peter MacKenzie, Jarrod Bogan
Episode 6
Masters and Johnson take on a famous couple hoping to renew their sex life.
Directed by Michael WeaverGuest stars Isabelle Fuhrman, Kevin Christy, Keir O'Donnell, Kristen Hager, Christopher Wiehl, Susan May Pratt, Daniel Rubiano, Frank Clem
Episode 7
Masters and Johnson are interviewed as they take on an exotic new patient.
Directed by Adam ArkinGuest stars Isabelle Fuhrman, Teddy Sears, Kevin Christy, Alex Borstein, Joe Tapper, Bruce Nozick, Frank Clem, Leah Verrill
Episode 8
Johnson jets away with Dan Logan. Masters begins his surrogacy program.
Directed by Matt Earl BeesleyGuest stars Teddy Sears, Kevin Christy, Sam McMurray, Grant Harvey, Whitney Anderson, Lauran September, Charlotte Bayne, Adriane Cade
Episode 9
Masters continues his surrogacy program, now under Johnson's critical eye.
Directed by Dan AttiasWritten by Jonathan IglaGuest stars Teddy Sears, Kevin Christy, Laura Silverman, Jerry O'Donnell, Blake Morgan Ferris, Bonnie Bower, Isabella Alexander, Clara James Daly
Episode 10
Johnson objects to Masters' program following missteps in the protocol.
Directed by Jeremy WebbGuest stars Isabelle Fuhrman, Kevin Christy, Kevin Fonteyne, Sascha Alexander, Brian Ibsen, Matthew McCollum, Ezekiel Bridges, Drew Marquardt
Episode 11
Agendas collide as Masters, Johnson, Logan and his wife meet for a dinner.
Directed by Susanna WhiteGuest stars Benjamin Koldyke, Maury Sterling, Yvonne Zima, Carly Waldman, Simon Vance, Timothy Durkin, Jonathan Kells Phillips, Jeff Lorch
Episode 12
Masters and Johnson find their life's work in jeopardy. Season finale.
Directed by Michael AptedGuest stars Kevin Christy, Emily Kinney, Colin Woodell, Heléne Yorke, Brian Howe, Josh Charles, Rob Benedict, Dennis Cockrum
Episode information updated Jul 24, 2026
Michael SheenWilliam Masters
Lizzy CaplanVirginia Johnson
Caitlin FitzGeraldLibby Masters
Annaleigh AshfordBetty DiMello
Nicholas D'AgostoEthan Haas
Isabelle FuhrmanTessa Johnson
Teddy SearsAustin Langham
Kevin ChristyLester Linden
ShowtimeUnited States
Sony Pictures TelevisionUnited States
Timberman/Beverly ProductionsUnited States
