TV series
William Masters and Virginia Johnson are real-life pioneers of the science of human sexuality. Their research touched off the sexual revolution and took them from a midwestern teaching hospital to the cover of Time magazine and multiple appearances on Johnny Carson's couch. He is a brilliant scientist out of touch with his own feelings, and she is a single working mother ahead of her time. The series chronicles their unusual lives, romance, and unlikely pop culture trajectory.
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Checked Jul 22, 2026
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William Masters and Virginia Johnson are real-life pioneers of the science of human sexuality. Their research touched off the sexual revolution and took them from a midwestern teaching hospital to the cover of Time magazine and multiple appearances on Johnny Carson's couch. He is a brilliant scientist out of touch with his own feelings, and she is a single working mother ahead of her time. The series chronicles their unusual lives, romance, and unlikely pop culture trajectory.
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Episode 1
In the wake of their fallout, Masters and Johnson search for purpose in a world without one another and look to work as their personal lives crash down around them. Libby finds herself alone for the first time since her marriage and discovers some unexpected allies. Season premiere.
Directed by Colin BuckseyGuest stars Alysia Reiner, Mary Birdsong, Brian Unger, Jake Lockett, Paul Cassell, Peter Holden, Alexis Genya, Candace Hammer
Episode 2
Masters and Johnson turn to new partners in an effort to put the past behind them and focus on their expanding clinic. Given their fractured triangle, Libby reevaluates her relationship with Bill and Virginia.
Directed by Jeremy WebbGuest stars Isabelle Fuhrman, Kevin Christy, John Billingsley, Rich Sommer, Erin Karpluk, Alex Weed, Kendra Andrews, Healy Lange
Episode 3
Masters and Johnson adjust to new partners, but their respective cases have them second-guessing the instinct to remain separated. A romantic prospect pushes Libby to embrace life as a newly single woman of the sexual revolution.
Directed by Adam ArkinGuest stars Kevin Christy, Judy Greer, John Gleeson Connolly, Bryce Johnson, Gabriel Tigerman, Andre Royo, Rachelle Dimaria, Jaret Sacrey
Episode 4
Johnson, Masters, Libby and Keller wind up together at a party thrown by Art and Nancy. Pairings and perspectives shift as the night wears on, until the light of day exposes the consequences of the evening.
Directed by Colin BuckseyGuest stars Kevin Christy, Ashley Zukerman, Amanda Quaid, David Conrad, Enuka Okuma, Rafael Feldman, Yan Feldman, Lily Rains
Episode 5
Johnson and Masters' troubles come to a head as the trial begins with Keller leading the charge. Virginia does her best to revive their career as Bill faces the reality of what the charges could mean for him, Johnson and the practice.
Directed by Eric TigniniGuest stars Matt McCoy, Jonathan Adams, Donald Sage Mackay, Tom Kiesche, Beth Kennedy, James Liebman, Joey Vahedi, Blair Fraser
Episode 6
Johnson looks to get her relationship with Masters back on track while Masters does his best to find satisfaction elsewhere. Betty and Helen ready themselves for a new addition; Art and Nancy discuss the consequences of their party.
Directed by Colin BuckseyGuest stars Kevin Christy, Joel Brooks, Sarah Silverman, Mike McColl, Elise Robertson, Julia McIlvaine, Melissa Center, Jamila Webb
Episode 7
Masters looks to groom Art as his protege in a new area of research as Johnson does her best to keep Nancy at arm's length. Betty seeks an unlikely source for assistance in her fight for equal rights to Helen's baby.
Directed by Michael AptedGuest stars Teddy Sears, Camryn Manheim, Jack Laufer, Rondi Reed, Ivar Brogger, Matthew Bohrer, Laura Schein, Hayes Hargrove
Episode 8
Masters and Johnson go on the road and pose as a couple to investigate practices at a competing clinic. While Bill and Virginia are away, Art, Nancy and Langham take advantage of their absence to further their own agendas.
Directed by Julie Anne RobinsonGuest stars Teddy Sears, Kevin Christy, Rick Peters, Charles Shaughnessy, Lisa Banes, Romy Rosemont, Stephen Root, Aaron Abrams
Episode 9
Masters and Johnson return from Topeka, each grappling with the trip's ramifications. Art and Nancy look to tie up loose ends in order to have a fresh start, and Libby embarks on a road trip with Bram that changes her perspective.
Directed by Karyn KusamaGuest stars Niecy Nash, Joanna Canton, Corey Reynolds, Jacqueline Hahn, Chelsea Maidhof, Michael Scott Allen, Julius Ritter, Melissa Blackwood
Episode 10
Masters and Johnson work to save the practice from disintegrating in the face of insurrection within the clinic. As everyone in their lives either moves on or falls away, Bill and Virginia find solace in one another. Season finale.
Directed by Michael AptedGuest stars Kevin Christy, Jaeden Martell, Jeremy Strong, Beau Bridges, Alyvia Alyn Lind, Danny Jacobs, Frances Fisher, Michael O'Keefe
Episode information updated Jul 24, 2026
Michael SheenWilliam Masters
Lizzy CaplanVirginia Johnson
Caitlin FitzGeraldLibby Masters
Annaleigh AshfordBetty DiMello
Nicholas D'AgostoEthan Haas
Isabelle FuhrmanTessa Johnson
Teddy SearsAustin Langham
Kevin ChristyLester Linden
ShowtimeUnited States
Sony Pictures TelevisionUnited States
Timberman/Beverly ProductionsUnited States
