Garterbelt, Briefs, and Zipper finally cry out in despair at the tyranny of the Angel Sisters and Devil Sisters. Garterbelt leaves the church and heads to Casino City with Briefs to fulfill her humble dream of spending a night at Casino City's strip bar! But...
Panty and Stocking are incarcerated in a bitch prison for being bitches. They team up with the Demon Sisters, who were previously incarcerated, to take part in a bitch football tournament, where if they win, they'll be acquitted!
It's Christmas Eve. Knee Socks is spending a quiet holiday alone, but when she goes to complain about the moaning sounds coming from Panty's room, she finds a bloodied old man with a white beard lying there.
Panty and Stocking are suddenly ordered to return to Heaven. The church crew is brought along to go with them, and Brief is overjoyed at the chance to visit Panty's family home...
Ramie is trying to unite the gods of Heaven. Panty, Stocking, the Demon Sisters, Garterbelt, and Brief have all been scattered—what fate awaits each of them!?