TV series
Ozzy & Drix, also known as The Fantastic Voyage Adventures of Osmosis Jones & Drixenol and Osmosis Jones: The Animated Series, is an American animated television series based on the Warner Bros. film Osmosis Jones and it was produced by Warner Bros. Animation. It takes place inside the body of teenager Hector Cruz. The series premiered on September 14, 2002 on the Kids' WB; the final episode aired July 5, 2004. Unlike the original movie it spun off from, Ozzy & Drix was entirely animated and contained no live action. It stars Phil LaMarr as the replacement for Chris Rock as Osmosis Jones, and Jeff Bennett as the replacement for David Hyde Pierce as Drix. As of July 2011, episodes of the series are still available via the Kids WB website. The show also aired on Teletoon in Canada. The show is also slightly less violent than the movie, having the characters treated like people rather than simply cells, and having none of them killed off, unlike the movie where Thrax managed to kill off several cells. There are also new characters that replace the ones from the original movie such as Maria Amino replacing Leah Estrogen, Mayor Spryman replacing Mayor Phlegmming, Sylvian Fischer replacing Tom Colonic, Chief Gluteus replacing The Chief of Police, The Mole replacing Chill the Flu Shot and Scarlet Fever replacing Thrax.
Availability
Ozzy & Drix premiered September 14, 2002. We don't have a confirmed streaming, rental or purchase option yet.
Ozzy & Drix, also known as The Fantastic Voyage Adventures of Osmosis Jones & Drixenol and Osmosis Jones: The Animated Series, is an American animated television series based on the Warner Bros. film Osmosis Jones and it was produced by Warner Bros. Animation. It takes place inside the body of teenager Hector Cruz. The series premiered on September 14, 2002 on the Kids' WB; the final episode aired July 5, 2004. Unlike the original movie it spun off from, Ozzy & Drix was entirely animated and contained no live action. It stars Phil LaMarr as the replacement for Chris Rock as Osmosis Jones, and Jeff Bennett as the replacement for David Hyde Pierce as Drix. As of July 2011, episodes of the series are still available via the Kids WB website. The show also aired on Teletoon in Canada. The show is also slightly less violent than the movie, having the characters treated like people rather than simply cells, and having none of them killed off, unlike the movie where Thrax managed to kill off several cells. There are also new characters that replace the ones from the original movie such as Maria Amino replacing Leah Estrogen, Mayor Spryman replacing Mayor Phlegmming, Sylvian Fischer replacing Tom Colonic, Chief Gluteus replacing The Chief of Police, The Mole replacing Chill the Flu Shot and Scarlet Fever replacing Thrax.
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Episode 1
Ozzy gets transfered into a girl named Christine's body when she gives Hector mouth-to-mouth when he jumps off the high dive to impress her, while there Ozzy starts changing colors and acting like a girl also he is arrested because they think he is a virus.
Directed by Del Barras, Dennis WoodyardWritten by Doug LangdaleGuest stars Cree Summer, Vivica A. Fox, Pat Fraley, Dawnn Lewis, Kimberly Brooks, Kevin Michael Richardson
Episode 2
Ozzy is still in Christine, using REM sleep (or Random Eye Movement). He calls Drix for help, thats when he learns he's gender morphing. When a cell from a certain gender goes to a body of another gender, that cell becomes that gender. With Drix's plan, and the help of another Drixinol cold pill in Christine called ""Drixina."" Ozzy might come back to Hector, and keep Christine from having pneumonia.
Directed by Del Barras, Dennis WoodyardWritten by Alan Burnett, Doug Langdale, Marc Gutman, Doug LangdaleGuest stars Cree Summer, Miriam Flynn, Vivica A. Fox, Pat Fraley, Dawnn Lewis, Kimberly Brooks, Kevin Michael Richardson
Episode 3
Everyone inside Hector forgets who Ozzy and Drix are when Hector experiences a concussion, forcing them to locate the site of the concussion, so they can reboot Hector's memories.
Directed by Del Barras, Dennis WoodyardWritten by Gene GrilloGuest stars Kath Soucie, Pat Fraley, Frank Welker, Rob Paulsen
Episode 4
Hector eats a sausage that he barely cooked and gets sick which leads him to getting two worms in his the male worm dies after mating, but the female survives, so Ozzy tries to kill it along with a crazy captain and Drix.
Directed by Del Barras, Dennis WoodyardWritten by Len UhleyGuest stars Jim Belushi
Episode 5
Hector discovers hair growing on his chin; testosterone gang ties up the mayor and wreaks havoc.
Directed by Del Barras, Dennis WoodyardWritten by Ray DeLaurentisGuest stars Joe Lala, Danny Cooksey, Hope Levy, Rob Paulsen
Episode 6
After getting injured on a police case, Maria is sent home to rest for the week. She decided to use this time to work on a family reunion coming up for her. Drix notices a rip on the corner of Maria's family picture. Maria doesn't seem to want to talk about it but then Ricky comes in and starts putting the puzzle pieces together. Maria and Ricky share their past with Drix which turns out as Ricky being the family prankster. Maria lost his trust in him so Drix decides to help Ricky get it back. He allows him to be a private eye along with Ozzy with not so good results.
Directed by Del Barras, Dennis WoodyardWritten by Len UhleyGuest stars Jeffrey Garcia
Episode 7
Hector uses a Nose spray to clear his nose, and Drix's Aunt appears. Suddenly, there's a drop in water in Hector and Ozzy thinks Drix's aunt is causing it.
Directed by Del Barras, Dennis WoodyardWritten by John P. McCannGuest stars Andrea Martin, Frank Welker, Rob Paulsen
Episode 8
Hector is super-sizing at fast-food resturaunts far too much, which gives Sticity, a bad cholestrial beatnik, the chance to kidnap a fat cell family's child, in an atempt to clog an artery. Can Ozzy and Drix (and the new navigational system, installed by Drix, named Backseat) return the huge blob to his parents in time?
Directed by Del Barras, Dennis WoodyardWritten by Steven DarancetteGuest stars Candi Milo, Charlie Adler, Dee Bradley Baker, Rob Paulsen
Episode 9
While snowboarding with Travis, Hector crosses an off limits area. Hector starts to freeride, but falls and makes a rip in his trousers. This causes a virus named Cryle to drop Hector's temperature. Ozzy and Drix get ready for a day at the beach, but have to stop Cryle from making Hecotr die of hypothermia.
Directed by Del Barras, Dennis WoodyardWritten by Ray DeLaurentisGuest stars Rob Paulsen, Susan Silo
Episode 10
When Hector accidently breathes in lead, the lead gang cause him to make him feel ill. The Mayor then makes Hector eat cereal so he can bring in The Supplements.
Directed by Del Barras, Dennis WoodyardWritten by Len Uhley
Episode 11
Ozzy goes into mitosis and a four armed evil clone doubles from him trying to steal the iodine.
Directed by Del Barras, Dennis WoodyardWritten by Alan Burnett, John Loy
Episode 12
Hector's appendix is about to burst.
Directed by Del Barras, Dennis WoodyardWritten by John Behnke, Rob HumphreyGuest stars Rob Paulsen, Frank Welker
Episode 13
Hector eats too much sugar and doesn't brush so he gets a cavity caused by General Malay.
Directed by Del Barras, Dennis WoodyardWritten by John P. McCann, Paul DiniGuest stars Charlie Adler
Episode information updated Sep 3, 2026
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Phil LaMarrOsmosis Jones (voice)
Jeff BennettDrix (voice)
Alanna UbachMayor Paul Spryman / Hector's Mom (voice)
Justin CowdenHector Cruz (voice)
Tasia ValenzaMaria Amino (voice)
Jim CummingsPolice Chief Gluteus (voice)
Jim BelushiCaptain Quinine (voice)
Cree SummerMayor Santorini (voice)
The WBUnited States
Warner Bros. AnimationUnited States