TV series
*Do not use as directed.
The causes and consequences of America's opioid epidemic unfold in this drama following its perpetrators, victims and an investigator seeking the truth.
Streaming, rental and purchase options
Checked Jul 22, 2026
Painkiller is available to stream on Netflix in United States. Use the direct links below to open the provider.
The causes and consequences of America's opioid epidemic unfold in this drama following its perpetrators, victims and an investigator seeking the truth.
Choose an episode, then use the watch options above for the show.
Episode 1
Seizing an opportunity, Richard bets on an opiate that relieves pain. College graduate Shannon takes a job at Purdue. Glen suffers a workplace injury.
Directed by Peter BergGuest stars Daniel Kash, Yasmin Lau, Caylie Mcrae, Dominique Smith, Mercedes Blanche, John Bydevaate, Sanjay Talwar, Natasha Bromfield
Episode 2
A patient using OxyContin attends a Purdue conference. Edie witnesses the drug's adverse effects. Richard faces roadblocks in his pursuit of profit.
Guest stars Kyle Gatehouse, Kathryn Bellamy
Episode 3
Glen is forced to detox when his addiction lands him in the ER. Edie struggles to convince her new boss, the US Attorney, to build a case against Purdue.
Guest stars Kyle Gatehouse
Episode 4
Edie works to expose Purdue. Shannon enjoys the perks of her job but faces a moral dilemma. Pushed to the brink, Glen starts losing control at work.
Guest stars Stuart Hughes, Lexie Galante, Sarah Curd, Megan Vincent
Episode 5
Glen hits rock bottom, Shannon attends a raucous work afterparty, and Edie uncovers damning evidence in her case against a pharmaceutical giant.
Guest stars Stuart Hughes, Megan Vincent, Keanu Lee Nunes, Kalie Hunter, Lisa Auguste, Kalliane Brémault, Lily McEvenue, Tracy Baker
Episode 6
Glen starts sobriety. Shannon reevaluates her role. Using new evidence, Edie and the team take Purdue to court as the case comes to a stunning end.
Guest stars Rosie Callaghan, Megan Vincent
Episode information updated Jul 23, 2026
Uzo AdubaEdie Flowers
Matthew BroderickRichard Sackler
Taylor KitschGlen Kryger
Dina ShihabiBritt Hufford
West DuchovnyShannon Schaeffer
John RothmanMortimer Sackler
Clark GreggArthur Sackler
Jack MulhernTyler Kryger
Netflix
Film 44United States
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