TV series
Painkiller Jane is an American-Canadian science fiction and action television series based on the comic book character of the same name. Airing on the Sci Fi Channel in the US starting April 13, 2007 and Global in Canada, it starred Kristanna Loken as the titular character. On August 15, 2007, it was canceled after one season of 22 episodes.
See where to watchStreaming, rental and purchase options
Checked Jul 22, 2026
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Painkiller Jane is an American-Canadian science fiction and action television series based on the comic book character of the same name. Airing on the Sci Fi Channel in the US starting April 13, 2007 and Global in Canada, it starred Kristanna Loken as the titular character. On August 15, 2007, it was canceled after one season of 22 episodes.
Cast, crew and production details
Kristanna LokenJane Vasco
Rob StewartAndre McBride
Noah Dalton DanbyConnor King
Stephen LoboSeth Carpenter
Sean Owen RobertsRiley Jensen
Nathaniel DeVeauxJoe Waterman
Alaina HuffmanMaureen Bowers
Tom ButlerDr. John Roberts
SyfyUnited States
Global TVCanada
Insight Film StudiosCanada
Insight FilmsMoroccoWatch options above are for the show and may vary by season or episode.
Episode 1
Jane Vasco with the help of a new covert government unit must track down and contain the spread of "Neuros," genetically altered humans with extraordinary powers.
Directed by Nick CopusWritten by Gil GrantGuest stars Nathaniel DeVeaux, Alaina Huffman, Adrian Holmes, Tiera Skovbye
Where to watch Painkiller Jane
Episode 2
When military stockpiles start to go missing before a presidential visit, Jane and the team are forced into high alert. Meanwhile, Jane confronts a Neuro with the ability to control the dead.
Directed by Michael RobisonWritten by Lawrence HertzogGuest stars Nathaniel DeVeaux, Alaina Huffman, Melanie Papalia
Where to watch Painkiller Jane
Episode 3
A Neuro with the ability to steal memory and knowledge preys on Riley putting the security of the entire operation in jeopardy.
Directed by Michael RobisonGuest stars Nathaniel DeVeaux, Alaina Huffman, Karen Kruper
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Episode 4
A Neuro who can see the future warns Jane and the team of their impending death on the day they arrest him. Meanwhile, the team is disturbed by the psychic's purchases
Directed by Farhad MannGuest stars Alaina Huffman, John Reardon
Where to watch Painkiller Jane
Episode 5
When inhabitants of an FBI safe house start to experience unexplained dreams and visions, Jane and crew must investigate potential Neuro activity.
Written by Lawrence HertzogGuest stars Alaina Huffman, Ken Tremblett, Anne Marie DeLuise
Where to watch Painkiller Jane
Episode 6
While investigating psychiatric patients who share the same unusual nightmare, Jane and Maureen suspect a Neuro has the ability to use nightmares as weapons.
Directed by William WaringGuest stars Alaina Huffman, Jenny Mitchell, Tiera Skovbye
Where to watch Painkiller Jane
Episode 7
The team investigate the suicides of individuals placed in witness protection and discover a Neuro who is capable of creating hallucinations.
Guest stars Alaina Huffman, Emy Aneke
Where to watch Painkiller Jane
Episode 8
Awakening in a hospital Jane learns that she murdered Riley. Meanwhile, Maureen investigates a doctor researching Neuros.
Directed by David TennantGuest stars Alaina Huffman, Tom Butler
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Episode 9
Connor is arrested for arson and murder while out hunting for a Neuro, which is believed to have started numerous house fires.
Written by Lawrence HertzogGuest stars Alaina Huffman
Where to watch Painkiller Jane
Episode 10
A young woman suddenly ages overnight, Jane and Maureen go undercover to find the cause.
Directed by Peter DeLuiseGuest stars Alaina Huffman, John Reardon, Meghan Ory, Melanie Papalia
Where to watch Painkiller Jane
Episode 11
Connor suffers a series of unfortunate events, believing it to be coincidental. However, he learns that members of his former police squad have died of strange causes.
Guest stars Nathaniel DeVeaux, Alaina Huffman, John Reardon
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Episode 12
Jane and Connor go undercover in a small town, posed as a married couple, after a federal agent's disappearance prompts an investigation.
Directed by Michael RobisonWritten by Lawrence HertzogGuest stars Nathaniel DeVeaux, Alaina Huffman, John Reardon, Barbara Tyson
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Episode 13
An investigation is started after Neuros begin to die before the team can apprehend them.
Directed by Paul ZillerGuest stars Paul Anthony, Jody Thompson, David Richmond-Peck
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Episode 14
Howie is a magician who can miraculously perform the impossible, which prompts Riley to begin an investigation into possible Neuro activity.
Guest stars John Reardon, Elias Toufexis
Where to watch Painkiller Jane
Episode 15
Sabotage hinders Jane's efforts to catch a Neuro, she becomes suspicious of a faith healer that she has been visiting.
Directed by Michael RobisonWritten by Charles HollandGuest stars John Reardon, Sonya Salomaa, Garwin Sanford, Clint Carleton
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Episode 16
Jane seeks help from a Neuro after Brian (Jane's boyfriend) and Joe forget who she is, the Neuro has the ability to remove and store memories within his mind.
Directed by Michael RobisonGuest stars Nathaniel DeVeaux, John Reardon, Megan Charpentier
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Episode 17
A Neuro causes the team to become stuck in a timeloop, causing them to relive the same day repeatedly. Meanwhile, the Neuro who caused the timeloop tries to finish an assassination.
Directed by Matthew HastingsWritten by George Schenck, Frank CardeaGuest stars Nathaniel DeVeaux, John Reardon, Dominic Zamprogna
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Episode 18
Jane discovers the disturbing truth about her abilities while searching for a Neuro who escaped the team.
Directed by Peter DeLuiseWritten by Lawrence HertzogGuest stars Tom Butler, John Reardon, Adrian Holmes, Sonja Bennett, Tiera Skovbye
Where to watch Painkiller Jane
Episode 19
The team respond when several incarcerated Neuros revolt and launch a prison break.
Directed by Matthew Hastings
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Episode 20
The residents of a small village are plagued by an invisible presence which is attacking and murdering the villagers.
Directed by Farhad Mann
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Episode 21
Andre encounters a Neuro from his past that was chipped, but he learns that she has regained her abilities and she has a grudge.
Directed by Matthew Hastings
Where to watch Painkiller Jane
Episode 22
Several dangerous Neuros launch a prison break after an emergency at NICO.
Directed by Farhad MannWritten by Gil Grant
Where to watch Painkiller JaneEpisode information updated Jul 22, 2026
