TV series
The headlines you remember, the ending you don't.
In this anthology series, heroic scientists risk all to deal with deadly outbreaks.
Streaming, rental and purchase options
Checked Sep 1, 2026
The Hot Zone is available to stream on Prime Video in United States. You can also rent or buy it from Google Play, Amazon, Apple TV, and Fandango at Home. Use the direct links below to open the provider.
In this anthology series, heroic scientists risk all to deal with deadly outbreaks.
Choose an episode, then use the watch options above for the show.
Episode 1
In Florida, a man mysteriously falls ill and dies. Special Agent Matthew Ryker suspects an anthrax attack - how many others have been infected?
Guest stars Harry Hamlin, Denyce Lawton, Morgan Kelly, Cody Ray Thompson, Michelle Giroux, Sochi Fried
Episode 2
Ryker’s investigation moves to New York as another case of anthrax occurs. Bruce Ivins begins having suspicions of his coworkers.
Guest stars Harry Hamlin, Denyce Lawton, Raven Dauda, Morgan Kelly, Enrico Colantoni, Lisa Ryder, Sochi Fried, William Poulin
Episode 3
An attack on Capitol Hill sends Ryker and his team to a mail facility that’s become a hot spot for anthrax infections.
Guest stars Dawn Olivieri, Denyce Lawton, Kristin Booth, Conrad Coates, William Poulin, Richard Waugh, Tony Craig
Episode 4
The FBI learns more about Bruce Ivins’ peculiar past behaviors after an old colleague raises red flags. Ryker and Dani trace the origin of the letters.
Guest stars Dawn Olivieri, Raven Dauda, Kristin Booth, Morgan Kelly, Conrad Coates, Richard Waugh, Ayesha Mansur Gonsalves, Chelsea Preston
Episode 5
All eyes shift to “Mr. Z.” As they start to zero in on a suspect, Ryker and Dani get new assignments - but that won’t stop them from chasing their lead.
Guest stars Dawn Olivieri, Raven Dauda, Morgan Kelly, Ayesha Mansur Gonsalves, Justin Mader, Martin Happer, Azeem Nathoo, Simon Webster
Episode 6
With two suspects in question, Ryker’s own beliefs about the case are tested.
Directed by Daniel PercivalWritten by Brian Peterson, Kelly SoudersGuest stars Dawn Olivieri, Denyce Lawton, Raven Dauda, Morgan Kelly, Ayesha Mansur Gonsalves, Justin Mader, Martin Happer, Jana Peck
Episode information updated Sep 14, 2026
Julianna MarguliesLt. Col. Nancy Jaax
Daniel Dae KimMatthew Ryker
Noah EmmerichLt. Col. Jerry Jaax
Tony GoldwynBruce Ivins
Nick SearcyFrank Mays
Liam CunninghamWade Carter
Dylan BakerEd Copak
James D'ArcyTrevor Rhodes
National GeographicUnited States
Fox 21 Television StudiosUnited States
National GeographicUnited States
Scott Free ProductionsUnited States
20th TelevisionUnited States
