TV series
The headlines you remember, the ending you don't.
In this anthology series, heroic scientists risk all to deal with deadly outbreaks.
Streaming, rental and purchase options
Checked Sep 1, 2026
The Hot Zone is available to stream on Prime Video in United States. You can also rent or buy it from Google Play, Amazon, Apple TV, and Fandango at Home. Use the direct links below to open the provider.
In this anthology series, heroic scientists risk all to deal with deadly outbreaks.
Choose an episode, then use the watch options above for the show.
Episode 1
Dr. Nancy Jaax has one of the most dangerous jobs in the world handling deadly viruses; after a lab accident, she is faced with a possible Ebola outbreak on U.S. soil.
Directed by Michael UppendahlWritten by James V. Hart, Kelly Souders, James V. Hart, Brian Peterson, Jeff Vintar
Episode 2
Dr. Nancy Jaax and her lab partner, Dr. Peter Jahrling, must take matters into their own hands to determine the source of the virus before it spreads; Dr. Jaax convinces an employee to hand over samples from infected monkeys.
Directed by Michael UppendahlWritten by James V. Hart, James V. Hart, Brian Peterson, Jeff VintarGuest stars Clark Backo, Sarah Allen
Episode 3
When representatives from varying agencies disagree on how to handle Dr. Nancy Jaax's discovery, she realizes there are few protocols in place for containing a deadly virus on U.S. soil; an employee at the monkey research facility falls ill.
Directed by Nick MurphyWritten by James V. Hart, Kelly Souders, James V. HartGuest stars Clark Backo, Sochi Fried, Grace Gummer, Rob Stewart
Episode 4
An employee at the monkey research facility falls ill, causing Dr. Nancy Jaax to fear the virus has spread to the human population; Jerry Jaax searches for a way to protect his wife; Dr. Wade Carter is obsessed with exposing the dangers of Ebola.
Directed by Nick MurphyWritten by James V. Hart, Brian PetersonGuest stars Rosemary Dunsmore, Ashton James, Libby Osler, Sochi Fried, Grace Gummer
Episode 5
Dr. Nancy Jaax works tirelessly to find out why the virus is behaving differently than expected in human victims; unforeseen dangers arise at the research facility; Jaax is forced to make a choice between her family and her duty to her country.
Directed by Nick MurphyWritten by James V. Hart, Kelly Souders, James V. Hart, Brian PetersonGuest stars Libby Osler, Sochi Fried, Grace Gummer, Rob Stewart
Episode 6
A volatile situation inside the research facility comes to a head; Dr. Jaax steps up, but exhaustion threatens the precision needed to sterilize the threat; the press arrives, and neighbors become aware of the danger next door.
Directed by Michael UppendahlWritten by Kelly Souders, Jeff Vintar, James V. Hart, Kelly Souders, Jeff VintarGuest stars Libby Osler, Grace Gummer
Episode information updated Sep 15, 2026
Julianna MarguliesLt. Col. Nancy Jaax
Daniel Dae KimMatthew Ryker
Noah EmmerichLt. Col. Jerry Jaax
Tony GoldwynBruce Ivins
Nick SearcyFrank Mays
Liam CunninghamWade Carter
Dylan BakerEd Copak
James D'ArcyTrevor Rhodes
National GeographicUnited States
Fox 21 Television StudiosUnited States
National GeographicUnited States
Scott Free ProductionsUnited States
20th TelevisionUnited States
